골육종으로 진행된 개화성 골 이형성증의 증례보고
A Case Report of Osteogenic Sarcoma Arising from Florid Osseous Dysplasia
김현실, 김남희, 육종인, 김진, 박혁, 차인호,
소속 상세정보
김현실 ( Kim Hyun-Sil ) - 연세대학교 치과대학 구강종양연구소
김남희 ( Kim Nam-Hee ) - 연세대학교 치과대학 구강종양연구소
육종인 ( Yook Jong-In ) - 연세대학교 치과대학 구강병리학교실
김진 ( Kim Jin ) - 연세대학교 치과대학 구강병리학교실
박혁 ( Park Hyok ) - 연세대학교 치과대학 구강악안면방사선과학교실
차인호 ( Cha In-Ho ) - 연세대학교 치과대학 구강악안면외과학교실
KMID : 0829220100340060383
Abstract
Osteogenic sarcoma is primary malignant bone tumor. It can arise de novo or from the benign precursors lesions, like Paget’s disease, giant cell tumor, chronic osteomyelitis, osteoblastoma, and fibrous dysplasia. Here, we present a case of osteogenic sarcoma arising from florid osseous dysplasia appearing as a rapidly growing bony bulging mass in 44-year-old Korean female who had at first been non-symptomatic, but later suffered from the numbness of chin and lower lip. The radiologic images revealed the mixed radiopaque- radiolucent intraosseous lesions throughout the mandible, which were diagnosed as florid osseous dysplasia pathologically. But only after 6 months, the lesions were substituted by the radiological ill-defined diffuse bony sclerotic lesion with bone destruction, accompanying the interrupted periosteal bone formation, which were pathologically diagnosed as osteogenic sarcomas. These serial clinicopathologic changes imply the malignant progression of florid osseous dysplasia rather than the collision of benign condition, florid osseous dysplasia and malignant tumor, osteogenic sarcoma. The possibility for fibro-osseous lesion of the jaw as premalignant lesion should not be overlooked; therefore, periodic check-ups for the lesions are necessary. Proper evaluation and interpretation for clinical neural symptom and radiologic change of bone density may lead to the correct differential diagnosis and therapeutic intervention.
키워드
Florid osseous dysplasia; Osteogenic sarcoma; Premalignant lesion; Fibro-osseous lesion
원문 및 링크아웃 정보
등재저널 정보